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Nucleoside Reverse Transcriptase Inhibitors

Nucleoside Reverse Transcriptase Inhibitors (NRTIs) are a class of antiretroviral medicines primarily used to treat human immunodeficiency virus (HIV) infections. They work by blocking the activity of the reverse transcriptase enzyme, which HIV requires to convert its RNA into DNA and reproduce inside host cells. These medicines act as defective building blocks during viral DNA synthesis, preventing further viral replication. NRTIs are commonly prescribed in combination with other antiretroviral drugs as part of combination antiretroviral therapy (ART). Common examples include zidovudine, lamivudine, emtricitabine, abacavir, and tenofovir.